摘要AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species.Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM),nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS).AEOL-10150 performed well in animal safety studies,and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated,indicating that AEOL-10150 has potential as a new catalytic antioxidant drug.In this article,we review improvements in AEOL-10150 in preclinical pharmacodynamic studies,especially regarding anti-SM,chlorine gas and radiation exposure studies.