Novel gene therapy for rheumatoid arthritis with single local injection:adeno-associated virus-mediated delivery of A20/TNFAIP3

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摘要Dear Editor, Multiple experiments have established TNF-α-induced protein 3 (A20/TNFAIP3) as a critical regulator associated with rheumatoid arthritis (RA)[1,2]. The lack of TNF-α-induced protein 3 (A20) promotes the NOD-like receptor protein 3 (NLRP3) inflammasome and induces spontaneous arthritis, while increase of A20 reduces the secretion of IL-1β and favors immunological tolerance[3,4]. Hence, we investigate the feasibility of recombinant adeno-associated virus 6 (rAAV6)-mediated A20 gene therapy in a collagen-induced arthritis (CIA) model.

作者 Qin Zhang ^[1] Fang-Xing Yu ^[2] Yang-Lin Wu ^[1] Cheng-Yuan Yang ^[3] Nai-Cheng Liu ^[3] Xu Zhu ^[3] Pi-Ming Zhao ^[2] Zhong-Ya Wang ^[2] Jun Lin ^[1] 学术成果认领

作者单位 Department of Orthopaedics,Suzhou Dushu Lake Hospital,Dushu Lake Hospital Affiliated to Soochow University,Medical Center of Soochow University,Suzhou 215001,Jiangsu,China;Department of Orthopaedics,the First Affiliated Hospital of Soochow University,Soochow University,Suzhou 215006,Jiangsu,China ^[1] Department of Gene Therapy,CureGenetics Co.,Ltd.,Suzhou 215021,Jiangsu,China ^[2] Department of Orthopaedics,the First Affiliated Hospital of Soochow University,Soochow University,Suzhou 215006,Jiangsu,China ^[3]

关键词 Adeno-associated virus Gene therapy Rheumatoid arthritis TNF-α-induced protein 3(A20)

栏目名称 LETTER TO THE EDITOR

发布时间 2023-07-12

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