摘要Dear Editor, The skin barrier can be impaired by acute skin wounds, which may lead to a series of complications. It is essential to accelerate wound healing and rapidly restore the structural integrity and functionality of skin. One of the promising bioactive agents is human salivary histatin 1 (Hst1), a 38-amino acid histidine-rich peptide that functions to maintain the homeostasis of oral mucosa with a cellular mechanism of promoting the adhesion, spreading, migration of epithelial cells and thus re-epithelialization[1]. In recent years, Hst1 has been shown to be effective against various skin-related cell types, such as fibroblasts, myo-fibroblasts, keratinocytes and endothelial cells. In our latest in vivo study, Hst1 not only promotes angiogenesis, re-epithelialization and collagen production, but also suppresses inflammation, thereby significantly accelerating acute skin wound healing in mice[2]. All these studies show that Hst1 is a potent bioactive agent for accelerating acute skin wound healing.