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BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition

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摘要Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment.

作者 Yu Meng ^[1] Hui-Yan Sun ^[2] Yi He ^[1] Qian Zhou ^[1] Yi-Huang Liu ^[1] Hui Su ^[1] Ming-Zhu Yin ^[1] Fu-Rong Zeng ^[3] Xiang Chen ^[1] Guang-Tong Deng ^[1] 学术成果认领

作者单位 Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008,China;National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Changsha 410008,China;Furong Laboratory,Changsha 410008,China;Hunan Key Laboratory of Skin Cancer and Psoriasis,Hunan Engineering Research Center of Skin Health and Disease,Xiangya Hospital,Central South University,Changsha 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha 410008,China ^[1] Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008,China;National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Changsha 410008,China;Furong Laboratory,Changsha 410008,China;Hunan Key Laboratory of Skin Cancer and Psoriasis,Hunan Engineering Research Center of Skin Health and Disease,Xiangya Hospital,Central South University,Changsha 410008,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha 410008,China;Department of Breast Reconstruction,Tianjin Medical University Cancer Institute and Hospital,Tianjin 300202,China ^[2] Department of Oncology,Xiangya Hospital,Central South University,Changsha 410008,China ^[3]

关键词 Melanoma Bromodomain and extra terminal domain(BET)inhibitor Ferroptosis Cell death AKR1C2 Immunotherapy

栏目名称

LETTER TO THE EDITOR

DOI 10.1186/s40779-023-00497-1

发布时间 2024-09-23（万方平台首次上网日期，不代表论文的发表时间）

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