换一批Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
摘要Background Diabetic cardiomyopathy is a disorder of the cardiac muscle that affects patients with diabetes.The exact mechanisms underlying diabetic cardiomyopathy are mostly unknown,but several factors have been implicated in the pathogenesis of the disease and its progression towards heart failure,including endothelial dysfunction,autonomic neuropathy,metabolic alterations,oxidative stress,and alterations in ion homeostasis,especially calcium transients[1].In Military Medical Research,Jiang et al.[2]sought to determine the functional role of complement factor D(Adipsin)in the pathophysiology of diabetic cardiomyopathy.
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关键词
AdipsinComplement factor DInterleukin-1Interleukin-1 receptor-associated kinase like 2(Irak2)Opa1Prohibitin(PHB)
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DOI
10.1186/s40779-023-00506-3
发布时间
2024-11-21（万方平台首次上网日期，不代表论文的发表时间）
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