摘要Dear Editor,The large defects of the skin caused by burns or trauma can result in disruption of the structure and function of the skin,as well as irreversible loss of skin appendages,such as sweat glands(SG).As the important modulator of temperature homeostasis,SG damage triggers heat intolerance and thermoregulatory dysfunction,which poses a considerable threat to health and quality of life[1-3].The promotion of wound healing with SG restoration remains a challenging issue.It has been reported that there are urinary epithelial cells(UECs)in human urine samples,and they may most likely originate from renal proximal tubules[4].UECs are easy to obtain from urine samples at any age,sex,or ethnic origin except for renal failure,with a cost-effective,non-invasive and simple isolation method[4].More importantly,the extensive source of clinical urine sample makes it easy for urinary cell autogenous transplantation and individualized treatment.Therefore,it is of great significance to convert UECs into urinary epithelial stem cells(UESCs)with repair ability.In this context,we design a strategy for the pharmacological conversion of UECs into UESCs,and the repair ability of UESCs in functional skin wound healing is explored.