首页 > 军事医学研究（英文版） > Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D

Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D

导出在线阅读解读下载全文终端阅读

二维码有效期 120s

点击刷新

注：终端设备浏览有效期：

学术成果认领

翻译打印收藏纠错

摘要Liver cancer,particularly hepatocellular carcinoma,remains a formidable challenge in medical research and requires a deeper understanding of its molecular underpinnings.In a fascinating recent study published in Military Medical Research,Xiong et al.[1]revealed the complex roles of F-box and leucine-rich repeat 6(FBXL6)and Kirsten rat sarcoma(KRAS)G12D in the pathogenesis of liver cancer.This research offers critical insights into how these proteins contribute to hepatocellular carcinoma development and progression,potentially paving the way for targeted therapeutic strategies.This commentary analyzes the key findings from this study and their broader implications in oncology.

作者 Qiang Cai ^[1] Quazi T.H.Shubhra ^[2] 学术成果认领

作者单位 Department of Neurosurgery,Renmin Hospital of Wuhan University,Wuhan 430060,China ^[1] Institute of Chemistry,University of Silesia in Katowice,41-500 Chorzów,Poland ^[2]

关键词 Hepatocellular carcinoma F-box and leucine-rich repeat 6(FBXL6)activation Kirsten rat sarcoma(KRAS)G12D mutation Mitogen-activated protein kinase(MEK)/mammalian target of rapamycin(mTOR)pathway Metastasis

栏目名称

COMMENTARY

DOI 10.1186/s40779-024-00515-w

发布时间 2025-04-22（万方平台首次上网日期，不代表论文的发表时间）

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交