摘要Objective: To investigate the value of systemic inflammatory response index (SIRI) and systemic immune-inflammation index (SII) in predicating acute appendicitis complications based on hemogram parameters. Methods: Demographic data, histopathological studies, and laboratory results of the patients who were admitted to the emergency department with a complaint of abdominal pain between January 2020 and June 2022 and were hospitalized with the diagnosis of acute appendicitis for operation by general surgery were examined. Simple appendicitis and complicated appendicitis groups were compared in terms of parameters according to their histopathological examinations. Results: A total of 220 patients who met the inclusion criteria were included in our study. Mean SIRI levels were found to be significantly higher in the complicated appendicitis group than in the simple appendicitis group [6.60 (4.07, 14.40) vs. 3.50 (2.20, 6.80); P=0.002]. Similarly, SII levels were found to be significantly higher in the complicated appendicitis group compared to the simple appendicitis group [2514.50 (1132.25, 5388.00) vs. 1207.00 (571.50, 2089.00), P<0.001]. The power of SIRI and SII to indicate complications was higher than white blood cell count and C-reactive protein (area under the curve: 0.753 and 0.786, respectively). Conclusion: SIRI and SII could be used to indicate complications in patients with acute appendicitis.