摘要Objective:To explore the underlying causes of death among vaccinated COVID-19 patients.Methods:The medical record of COVID-19 patients admitted to the main COVID-19 referral center in southeast Iran from January to March 2022 was investigated.Then,risk factors for mortality were statistically assessed.Results:92 patients were included,with 50 in infectious disease ward and 42 in ICU ward.In total,37%of patients succumbed to COVID-19.The median age of those who died was 69.9 years.Dementia and genitourinary system-related diseases was associated with an increased risk of death[6.00(95%CI:1.14-31.66)and 4.93(95%CI:1.80-13.52)].Furthermore,the elevated levels of white blood cells,neutrophils,lactate dehydrogenase,blood urea nitrogen,and creatinine were associated with an increased risk of death by 4.93(95%CI:1.82-13.36),16.57(95%CI:2.10-131.31),3.23(95%CI:1.15-9.03),4.48(95%CI:1.78-11.31),and 4.27(95%CI:1.49-12.22),respectively.Conclusions:Despite receiving the SARS-CoV-2 vaccine,individuals who suffer from dementia and genitourinary system-related diseases are at risk of death with new strains of SARS-CoV-2 infection.Furthermore,the increase of white blood cell,neutrophils,lactate dehydrogenase,blood urea nitrogen,and creatinine in patients'blood can be considered as warning indicators of disease progression and death.