摘要目的:基于冠状动脉CTA影像的无创血流储备分数（FFR-CT）与有创冠状动脉血流储备分数（FFR）的有效性对照研究。方法:本研究共回顾性纳入47例（61支病变血管）患者，采用杭州脉流科技有限公司的AccuFFR ?ct原型软件系统（AccuFFR ?ct, version 1.0）计算每个狭窄处的FFR-CT值，并与有创FFR值进行比较，以FFR≤0.8为具有血流动力学意义的狭窄为参照，通过准确性、敏感性、特异性、阳性预测值（PPV）和阴性预测值 （NPV）以及计算在受试者操作特征（ROC）曲线下的面积（AUC）来评价FFR-CT的有效性。 结果:对每个患者的FFR-CT与有创FFR相比的准确率为91.5%，敏感性为88.2%，特异性为93.3%，PPV为88.2%，NPV为93.3%；对于每条血管相应的值分别为88.5%、88.2%、88.6%、75%和95.1%。FFR-CT和有创FFR之间存在显著的相关性（患者水平： r=0.71， P<0.0001，和血管水平： r=0.62， P<0.0001），并且AUC值分别为0.89和0.90。 结论:基于冠状动脉CTA影像计算的AccuFFR ?ct系统可以作为评估冠状动脉狭窄引起功能性缺血的一种快速、准确的计算工具。

abstractsObjective:To compare non-invasive coronary blood fractional flow reserve based on coronary CTA (FFR-CT) imaging with invasive coronary blood fractional flow reserve (FFR).Methods:Totally 47 patients (61 lesions) were retrospectively collected in this study, The FFR-CT value at each stenosis was calculated by AccuFFR ?ct (version 1.0, ArteryFlow Technology Co., Ltd.) and evaluated with accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and the area under the receiver operating characteristic (ROC) curve (AUC) , with FFR≤0.8 as the reference for the diagnosis of hemodynamically significant coronary stenosis. Results:The accuracy, sensitivity, specificity, PPV and NPV of AccuFFR ?ct versus invasive FFR were 91.5%, 88.2%, 93.3%, 88.2%, and 93.3% for the patient-level. The corresponding values for the vessel-level were 88.5%, 88.2%, 88.6%, 75% and 95.1%, respectively. There was a significant correlation between FFR-CT and invasive FFR (patient-level r=0.71, P<0.0001, and vessel-level r=0.62, P<0.0001, respectively), with AUC values of 0.89 and 0.90, respectively. Conclusions:AccuFFR ?ct method based on coronary CTA imaging can be used as a fast and accurate tool to evaluate the functional significance due to coronary artery stenosis.