摘要The problem of iron overload in non-transfusion-dependent-thalassemia (NTDT) has gradually attracted people's attention.Invalid overproduction of red blood cells in vivo,which induces hepcidin expression decrease and prompts increased intestinal iron absorption,leads to iron overload.The second complications resulting from iron overload affect NTDT patient's quality of life and life expectancy.Iron chelator is the only effective therapy at present.The adverse events and other limits urge us to find novel ways to cure the iron over-load.Currently,in Hbbth3/+ mouse model,increasing hepcidin expression through different methods can achieve better therapeutic effect of chelation,however,the clinical safety and effect of this way is not yet clear.