摘要Introduction:This is the first case of Transcatheter Aortic Valve Replacement(TAVR)in the prefec-ture level hospital of Xinjiang Province in China.It also proves that severe left main coronary artery disease(LM)is not the contraindication to this operation of TAVR.Patient concerns:The patient had dyspnea for two years,with the 4/6 spurious murmur at the aortic valve.The cardiac ultrasound revealed a severe aortic valve stenosis(AS)and severe mitral regurgitation(MR).Coronary angiography(CAG)showed 80％stenosis of the left main artery.Diag-nosis:The severe aortic valve stenosis(AS).Interventions:He received the TAVR,which also is the first case in the First People's Hospital of Kashi Prefecture.Outcomes:The patient's symptoms were significantly improved.The cardiac ultrasound showed that no obvious regurgitation was found in the implanted artificial aortic valve and the MR was significantly reduced.So far,the patient has recovered well for five months after TAVR.Conclusion:TAVR is an effective method for the severe AS patients with serve LM and loss of surgical opportunity.