摘要Summarized a case of intraoperative nursing experience in a second-trimester patient with mitral bio-prosthetic valve destruction undergoing median mitral valve technique with zero contrast agent.In this case,a pa-tient with 18 weeks of intrauterine pregnancy after artificial insemination,who had a sudden palpitation,was sent to the hospital in an emergency and diagnosed with severe intravalvular regurgitation and severe pulmonary hyperten-sion after mitral artificial biological valve replacement.A treatment plan was developed after the systematic and comprehensive evaluation of the condition of the patient under a multi-disciplinary combination.Intraoperative nursing cooperation,patient condition monitoring,fetal X-ray protection,prevention of massive bleeding,sudden arrhythmia,and other emergency rescue cooperation were implemented in the processing of surgery,and no intraop-erative nursing complications occurred.The patient recovered and was discharged from the hospital.The pregnancy was terminated by cesarean section after full term and the newborn survived with no deformity.