摘要Background The relationship between estimated glomerular filtration rate(eGFR)and depression in patients with coronary artery disease(CAD)remained unclear.Methods A total of 561 patients with CAD were selected from Department of Cardiology between October 2017 and February 2018 while their depression status was evalu-ated by Patient Health Questionnaire-9(PHQ-9).The eGFR levels were compared between patients with and with-out depression and the link between eGFR and depression in CAD patients was explored.Results Among 561 CAD patients,63 patients(11.23％)were diagnosed with comorbid depression(PHQ-9≥10).The depression group presented significantly lower eGFR level than the non-depression group.In fully-adjusted multivariate analysis,higher eGFR level was proved to be a protective factor for depression in CAD patients,reducing a 22％risk of de-pression for every 10 mL/(min·1.73 m2)increase of eGFR level(OR:0.78,95％CI:0.66-0.93).Similar results were found in the stratified analyses of both eGFR quartiles and chronic kidney disease(CKD)stages(P for trend＜0.05),while no significant differences were found among subgroups(P for interaction＞0.05).A negative linear as-sociation was estimated between eGFR level and depression in CAD patients.Conclusions Our results suggested lower eGFR level in CAD patients with comorbid depression,displaying a negative linear correlation between eG-FR and risk of depression in CAD patients.The findings implied that screening depression in CAD patients with de-creased eGFR level or concomitant CKD should be highlighted in clinical practice.[S Chin J Cardiol 2024;25(1):1-10]