摘要Background Although neutrophil-to-lymphocyte ratio(NLR)has been extensively studied in several diseases,its predictive role in infective endocarditis(IE)complicated with sepsis remains unclear.The aim of this study was to explore the prognostic value of NLR in IE patients complicated with sepsis.Methods Patients with the diagnosis of IE complicated with sepsis was retrospectively enrolled between January 2009 to February 2020 in the Guang-dong Provincial People's Hospital.Multivariate analysis was used to investigate the relationship between NLR and short-term mortality.Results A total of 496 IE patients complicated with sepsis were included and divided into three groups according to the tertiles of NLR:＜4.3(n=161),4.3-8.7(n=170),and＞8.7(n=165).Restricted cubic splines showed an approximately positive linear correlation between the level of NLR and risk of in-hospital death.Multivariate logistic regression analysis showed an independent correlation between elevated NLR and in-hospital death[odds ratio(OR):1.04,95％confidential interval(CI):1.01-1.07,P=0.015].The receiver operating character-istic curve analysis demonstrated a relatively high predictive value of NLR for identifying in-hospital death(area under curve:0.643,95％CI:0.570-0.717,P＜0.001,sensitivity:45.1％,specificity:81.6％,optimal cut-off value:11).Multivariate Cox survival analysis revealed that NPR＞11(HR:1.57,95％CI:1.02-2.41,P=0.039)was inde-pendent predictor for 6-month mortality.Conclusions NLR is a feasible predictor of short-term mortality for IE patients complicated with sepsis.[S Chin J Cardiol 2024;25(4)-.245-251]