摘要Heart failure (HF) is a condition of cardiac dysfunction and fluid overload.Neurohormonal activation via the reninangiotensin-aldosterone system and the sympathetic nervous system are the pathophysiological cornerstones.[1] Furthermore,HF is a disorder widely associated with grave adverse outcomes and poor prognosis.[2] A loop diuretic is the fundamental drug used to prevent multiorgan failure and improve symptoms in these patients.[3] Noteworthy worries have been put forth concerning the risks and benefits of loop diuretics,particularly about the dosage and administration procedure.[4,5] Several observational studies have shown that static drug exposure is associated with increased mortality risk.[6-15] Loop diuretics administered as a continuous infusion have been thought to convey further benefits over bolus injections.