摘要BACKGROUND Oxidative stress is closely associated with hypertensive outcomes.The oxidative balance score(OBS)measu-res oxidative stress exposure from dietary and lifestyle elements.The objective of this study was to investigate the association be-tween OBS and mortality in hypertensive patients.METHODS This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey(NHA-NES)1999-2014.Several models,including Cox regression,restricted cubic splines(RCS),Kaplan-Meier survival analysis,subgr-oup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of mortality.RESULTS Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio(HR)=0.90,95％CI:0.85-0.95]and cardiovascular mortality(HR=0.85,95％CI:0.75-0.95).With adjust-ment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust(all-cause mortality:HR=0.91,95％CI:0.86-0.96;cardiovascular mortal-ity:HR=0.85,95％CI:0.76-0.96).RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortal-ity risk(Pnonlinear=0.088 and Pnonlinear=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS(P＜0.001).The consistency of the association was demonstrated in subgroup and sensitivity analyses.RCS after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never drinkers.CONCLUSIONS In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular mortality.Encouraging hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be bene-ficial in improving their prognosis.