摘要BACKGROUND Limited research has explored the impact of cardiovascular disease(CVD)on healthy life expectancy(HLE)especially in resource-limited areas.This study aimed to investigate the association between CVD and HLE in Chinese rural pop-ulation.METHODS This study included 11,994 participants aged 45 years and older from the baseline and follow-up surveys of the Henan rural cohort study.Healthy status was measured via a Visual Analogue Scale.The multistate Markov model was applied to estimate the association between CVD and transitions in health,unhealthiness and death.Gender-specific total life expectancy,HLE and unhealthy life expectancy were calculated by the multistate life table method.RESULTS During a mean follow-up time of 3.85(3.84-3.86)years,there were 588 deaths recorded.For individuals with CVD,the risk of switching from health to unhealthiness status was increased by 71％[hazard ratio(HR)=1.71,95％CI:1.42-2.07],the chance of recovery was reduced by 30％(HR=0.70,95％CI:0.60-0.82).Men aged 45 years without CVD could gain an extra 7.08(4.15-10.01)years of HLE and lose 4.00(1.60-6.40)years of unhealthy life expectancy compared to their peers with CVD,respect-ively.The corresponding estimates among women were 8.62(5.55-11.68)years and 5.82(2.59-9.04)years,respectively.CONCLUSIONS This study indicated that CVD was significantly associated with poorer health status and lower HLE among Chinese rural population.It is an important public health policy to adopt targeted measures to reduce the CVD burden and en-hance the quality of life and HLE in resource-limited areas.