摘要Background Both medication and non-medication therapies are effective approaches to control blood pressure(BP)in hyper-tension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index(HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective interven-tion studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention(n=40)and control(n=20)groups.Basic information on employees at each workplace was collected by trained pro-fessionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which in-cluded:(1)a workplace wellness program for all employees;(2)a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale(range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as tak-ing drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included(age:46.3±7.6 years,men:3547(82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking(OR=0.65,95%CI:0.43-0.99;P=0.045),drinking(OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise(OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food(OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt(OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used(OR=2.34;95%CI:1.16-4.72;P=0.017)or changed from not using to using antihypertensive medication(OR=2.24;95%CI:1.08-4.62;P=0.030)had higher BP control.Compared with those having lower HLI,participants with a same(OR=1.38;95%CI:0.99-1.93;P=0.056)or high(OR=1.79;95%CI:1.27～2.53;P<0.001)HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control(OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associ-ated with a significant improvement in BP control among employees with hypertension.