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神经精神药理学治疗药物监测共识指南:2017版

摘要(上续本刊2022年1期20页)2. 2 剂量相关参考浓度范围对于TDM结果的解释,除了治疗参考浓度范围外还有另一个浓度范围,即所谓的剂量相关参考浓度范围.治疗参考浓度范围的应用是药效动力学问题,而剂量相关参考浓度范围的运用是药代动力学问题.后者比较的是测得的药物浓度与理论预期药物浓度范围.参照药代动力学研究,优先考虑没有合并用药或药物基因组异常的患者群("正常"患者) ,在日维持剂量( Daily maintenance dose, Dm)、给药间隔(Dosing interval,di)、总清除率(Total clear-ance,CL)和生物利用度( Bioavailability,F)已知情况下,某种药物在某个"正常"患者体内的预期平均稳态浓度( Aver-age steady-state concentration,Cav )可通过下面的公式计算:

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作者 C. Hiemke [1] N. Bergemann [2] H. W. Clement [3] A. Conca [4] J. Deckert [5] K. Domschke [6] G. Eckermann [7] K. Egberts [8] M. Gerlach [8] C. Greiner [9] G. Gründer [10] E. Haen [11] U. Havemann-Reinecke [12] G. Hefner [13] R. Helmer [14] G. Janssen [15] E. Jaquenoud [16] G. Laux [17] T. Messer [18] R. M?ssner [19] M. J. Müller [20] M. Paulzen [10] B. Pfuhlmann [21] P. Riederer [5] A. Saria [22] B. Schoppek [23] G. Schoretsanitis [24] M. Schwarz [25] M.Silva Gracia [11] B. Stegmann [11] W. Steimer [26] J. C. Stingl [9] M. Uhr [27] S. Ulrich [28] S. Unterecker [5] R. Waschgler [29] G. Zernig [30] G. Zurek [31] P. Baumann [32] 李文标 [33] 果伟 [33] 贺静 [33] 鲍爽 [33] 路钊 [33] 牛梦溪 [33] 阮灿军 [33] 臧彦楠 [33] 王勇 [34] 张玲 [33] 刘辰庚 [33] 李洁 [34] 学术成果认领
作者单位 Department of Psychiatry and Psychotherapy,University Medical Center of Mainz,Mainz,Germany;Institute of Clinical Chemistry and Laboratory Medicine,University Medical Center of Mainz,Mainz,Germany [1] Kitzberg Hospitals,Center for Psychosomatic Medicine and Psychotherapy,Bad Mergentheim,Germany [2] Department of Child and Adolescent Psychiatry,University of Freiburg,Freiburg,Germany [3] Servizio Psichiatrico del Comprensorio Sanitario di Bolzano,Bolzano,Italy [4] Department of Psychiatry,Psychotherapy and Psychosomatics,University Hospital of Würzburg,Germany [5] Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg,Freiburg,Germany [6] Psychiatric Hospital,Kaufbeuren,Germany [7] Department of Child and Adolescent Psychiatry,Psychosomatics and Psychotherapy,Center of Mental Health,University Hospi-tal of Würzburg,Germany [8] Federal Institute for Drugs and Medical Devices (BfArM),Bonn,Germany [9] Department of Psychiatry,Psychotherapy and Psychosomatics,RWTH Aachen University,Aachen,and JARA–Translational Brain Medicine,Aachen,Germany [10] Clinical Pharmacology,Department of Psychiatry and Psychotherapy and Department of Pharmacology and Toxicology,Uni-versity of Regensburg,Regensburg,Germany [11] Department of Psychiatry and Psychosomatics,University of G?ttingen,G?ttingen,Germany [12] Psychiatric Hospital,Vitos Klinik,Eichberg,Eltville,Germany [13] Center of Epilepsy,Bielefeld,Germany [14] Medical Laboratory Stein,Limbach Group,M?nchengladbach,Germany [15] Psychiatric Hospital,K?nigsfelden,Brugg,Aargau,Switzerland [16] Institute of Psychological Medicine,Haag in Oberbayern,Germany [17] Danuviuskliniken,Psychiatric Hospital,Pfaffenhofen,Germany [18] Department of Psychiatry and Psychotherapy,University of Tübingen,Tübingen,Germany [19] Psychiatric Hospitals Oberberggruppe,Berlin,Germany [20] Psychiatric Hospital Weisser Hirsch,Dresden,Germany [21] Experimental Psychiatry Unit,Department of Psychiatry1,Medical University of Innsbruck,Innsbruck,Austria [22] kbo-Isar-Amper Klinikum München-Ost,Psychiatric Hospital,Munich-Haar,Germany [23] Department of Psychiatry,University of Bern,Bern,Switzerland [24] Department of Laboratory Medicine,Ludwig Maximilian University,Munich,Germany [25] Institute of Clinical Chemistry and Pathobiochemistry,Technical University Munich,Munich,Germany [26] Max Planck Institute of Psychiatry,Munich,Germany [27] Aristo Pharma GmbH,Berlin,Germany [28] Psychiatric Hospital,Feldkirch,Austria [29] Experimental Psychiatry Unit,Department of Psychiatry1,Medical University of Innsbruck,Innsbruck,Austria;Private Practice for Psychotherapy and Court-Certified Witness,Hall in Tirol,Austria [30] Medical Laboratory Bremen,Bremen,Germany [31] Department of Psychiatry,University of Lausanne,Prilly-Lausanne,Switzerland [32] 中国 北京 首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京重点实验室 [33] 中国 天津 天津市安定医院 [34]
栏目名称
DOI 10.14053/j.cnki.ppcr.202202001
发布时间 2022-03-23(万方平台首次上网日期,不代表论文的发表时间)
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