摘要目的 比较单纯肝动脉化疗栓塞术(TACE)和联合腹腔灌注、中药辅助治疗及免疫治疗原发性肝细胞癌的疗效及毒副作用.方法 将216例原发性肝细胞癌随机分为两组,A组104例,单纯行TACE;B组112例,TACE+腹腔灌注化疗+中药辅助治疗+免疫治疗.结果 近期有效率A组为28.84%,B组为34.82%;4年生存率A组1.92%,B组3.57%,差异有统计学意义(P<0.05).治疗后两组均无严重并发症发生.结论 B组的近期疗效和4年生存率均优于A组、两组副反应率差异无统计学意义.

abstractsObjective To compare the therapeutic efficacy and adverse effects between transcather arte-rial chemoembolization(TACE) and comprehensive therapy in primary advanced heptocellular carcinoma(HCC).Methods 216 patients with primary HCC were arranged randomly into two groups:104 (group A) were treated with TACE alone,the rest(group B)were treated with TACE combined with intraperitoneal perfusion chemothera-py, Chinese herbs and immunotherapy.The therapeutic efficacy and adverse effects were analysed and compared between two groups.Results The CR + PR rates were 28.84% in group A and 34.82% in group B.The 4-year survival rates were 1.92% in group A and 3.87% in group B(P < 0.05).There were no severe side effects in both groups.Conclusions The short-term effective rate and 4-year survival rate in comprehensive treatment group were superior to the control group.Therefore, the comprehensive treatment is worthwhile to use in primary advanced hepatocellular carcinoma.