摘要目的 探讨双侧甲状腺癌的诊断和治疗方法.方法 回顾性分析68例双侧甲状腺癌的临床资料.结果 行甲状腺全切+双侧功能性清扫22例,全切+单侧功能性清扫30例,全切+Ⅵ区淋巴结清扫14例,姑息性手术2例.12例术后131I治疗.术后并发症:5例单侧短暂喉返神经麻痹;1例双侧永久性喉返神经损伤经气管切开,带管生存;1例气管软化,窒息,经气管切开,带管生存;6例短暂低血钙抽搐;1例永久性甲状旁腺功能低下;2例术后乳糜瘘,1例手术缝扎治愈,1例保守治疗治愈.术前B超均发现甲状腺内实性或囊实性低回声结节,结节内有钙化38例(55.88%);针吸细胞学确诊42例,术中快速病理证实64例(94.12%).63例获随访,随访率为92.64%,随访6个月至5年,5例复发转移,经再次手术切除,除1例未分化癌术后6个月死亡,余均存活.结论 甲状腺全切+颈部淋巴清扫是双侧甲状腺癌的主要术式,术前高频B超提示甲状腺结节内微钙化灶对术前诊断有重要意义.

abstractsObjective To investigate the diagnosis and treatment of bilateral thyroid carcinoma(BTC).Methods Clinical data of 68 cases with BTC from July 2001 to July 2008 were analyzed retrospectively.Results All patients underwent surgical treatment.22 cases received total thyroidectomy and bilateral functional neck dissection,30 cases received total thyroidectomy and unilateral functional neck dissection,14 cases received total thyroidectomy and lymph node dissection of Ⅵ area,2 cases received palliative resection.12 cases received proper radioactive 131I therapy after operation.Postoperative complications occured in 16 cases,including 5 cases with transient recurrent nerve paralysis,1 case with permanent injury of recurrent laryngeal nerves received trachea incision,1 case with tracheomalacia and asphyxia,6 cases with convulsion caused by hypocalcemia,1 case with permanent hypoparathyroidism,2 cases with chylous fistula(one was cured by saturing and ligaturing and the other by conservative treatment).Low echo solid or cystic solid nodules in thyroid were found by preoperative ultrasonic scan in all cases,in which 38(55.88%)cases were associated with gravel calcified lesion in thyroid nodules.The diagnosis was comfirmed by needle aspiration biopsy(NAB)in 42 cases preoperatively and 64 cases(94.12%)by frozen section intraoperatively.63(92.64%)cases were followed up postoperatively for a period from 6 months to 5 years,all 5 cases with recurrence and/or metastasis had tumor-free survival after reoperation except for 1 case with undifferentiated cancer died on the 6th month after operation.Conclusions Total thyroidectomy and lymph node dissection is essential to the treatment of BTC.Gravel calcified lesion revealed by preoperative high frequency ultrasonagraphy is an important characteristic for preoperative diagnosis of thyroid cancer.