摘要Objective:Pelvic organ prolapse(POP)is a common gynecological disease in middle-aged and older women that seriously affects patients'physical health and quality of life,increases the financial burden for patients,and becomes a major public health concern.The aim of this study was to investigate the medium-term outcomes of laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach for patients with severe POP.Methods:Patients with severe POP quantitation stage Ⅲ-Ⅳ who underwent laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with a posterior approach at the Department of Obstetrics and Gynecology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine between September 2016 and December 2020 were enrolled in this study.The results and complications were recorded.Data were retrospectively reviewed.Results:In total,124 patients were analyzed.Patients were followed up for 32.27±12.90 months.The objective cure rate for patients who underwent hysterectomy was 91.7％(100/109),with 7(6.4％)patients had anterior vaginal wall prolapse and 2(1.8％)patients had posterior vaginal wall prolapse.The objective cure rate for patients who retained uterus was 66.7％(10/15).All 5 patients with recurrence had uterine prolapse,and 3(20.0％)of them also had anterior vaginal wall prolapse.Conclusions:Laparoscopic pubocervical fascia reconstruction and sacrospinous ligament fixation with the posterior approach is a safe,minimally invasive,and effective method for patients with severe POP.Long-term follow-up is needed to confirm the clinical effects.