受体-受体相互作用:神经递质受体功能的一种重要调控机制
Receptor-receptor interaction: a critical mechanism for the regulation of neurotransmitter receptor function
摘要1 Introduction Neurotransmitter receptors are proteins embedded in the synaptic plasma membrane where they play a dual role in synaptic transmission.First,receptors have domains that extend into the synpatic cleft and bind neurotransmitters/agonists that are released into this space from the presynaptic neuron.Second,the binding of neurotransmitters to these domains open or close ion channels directly or indirectly in the postsynaptic membrane,or activate signalling events in the postsynaptic neuron,thus mediating the transfer of information across the synapse[1 ].
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