摘要Sepsis poses a serious threat to health of children in pediatric intensive care unit.The mortality from pediatric sepsis can be effectively reduced through in-time diagnosis and therapeutic intervention.The bacilliculture detection method is too time-consuming to receive timely treatment.In this research,we propose a new framework:a deep encoding network with cross features(CF-DEN)that enables accurate early detection of sepsis.Cross features are automatically constructed via the gradient boosting decision tree and distilled into the deep encoding network(DEN)we designed.The DEN is aimed at learning sufficiently effective representation from clinical test data.Each layer of the DEN filtrates the features involved in computation at current layer via attention mechanism and outputs the current prediction which is additive layer by layer to obtain the embedding feature at last layer.The framework takes the advantage of tree-based method and neural network method to extract effective representation from small clinical dataset and obtain accurate prediction in order to prompt patient to get timely treatment.We evaluate the performance of the framework on the dataset collected from Shanghai Children's Medical Center.Compared with common machine learning methods,our method achieves the increase on F1-score by 16.06％on the test set.