颌面部骨结构部位特异性重建的组织工程技术:第1部分

A Tissue Engineering Approach to Site-Specific Reconstruction of Skeletal Structures of the Maxillofacial Region:PartⅠ

二维码有效期 120s

摘要本文论述了骨、软骨组织工程构建中支架的影像学设计和制作方法.我们的组织工程化骨和(或)软骨支架为三维设计制作的生物可降解支架,按颌面部重建部位进行个体化设计. 这种经过特制的支架能够将生物刺激传入位于其间隙内的种植细胞.这些生物刺激信号可影响植入支架内的间充质干细胞(MSC)或骨髓基质细胞(BMSC),从而形成面部重建所需的组织 .这种颌面部组织工程新技术具有优点,一方面符合重建位的解剖形态;另一方面能够在行使功能时,适应功能力量而发生改建.本文以颞下颌关节(TMJ)髁突-升支区重建为例,对这一新技术作一详细介绍.

作者单位 Associate Professor, Department of Oral & Maxillofacial Surgery, Schools of Den tistry and Medicine, University of Michigan, Ann Arbor, Michigan ^[1] Associate Professor, Departments of Biomedical Engineering and Mechanical Engi neering and Applied Mechanics, College of Engineering, and Department of Surgery , School of Medicine, University of Michigan, Ann Arbor, Michigan ^[2] Professor, Department of Material Sciences and Engineering, College of Enginee ring, University of Michigan, Ann Arbor, Michigan ^[3] Post-Doctoral Fellow, Department of Material Sciences and Engineering, Colleg e of Engineering, University of Michigan, Ann Arbor, Michigan ^[4] Assistant Professor, Department of Oral Medicine, Pathology and Oncology, Scho ol of Dentistry, University of Michigan, Ann Arbor, Michigan ^[5]

关键词组织工程支架重建颌面部 Tissue Engieering Scaffolds Reconstruction Maixi llofacial Region

主题词组织工程(Tissue Engineering)支架(Stents)敏感性与特异性(Sensitivity and Specificity)软骨(Cartilage)细胞(Cells)

分类号 R782.2

栏目名称 组织工程技术

发布时间 2004-01-08