摘要BACKGROUND:The increasing morbidity of liver cancer has led to a growing demand for transplantation.Split liver transplantation(SLT)is a promising way to ameliorate organ shortages.However,the safety and efficacy of SLT are still controversial.The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center.METHODS:A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied,of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT).Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS:SLT and WGLT were successfully performed,with no intraoperative transplant-related mortality.Postoperatively,no significant differences in total bilirubin(TB,P=0.266),alanine transaminase(ALT,P=0.403)and aspartate transaminase(AST,P=0.160)levels within 30 d were detected between the two groups.The transplant-related mortality rates were 8.1%in the SLT group and 5.4%in the WGLT group within 30 d of surgery(P=1.000),and 10.8%and 8.1%,respectively,at 90 d after surgery(P=1.000).There were no significant differences in overall survival(OS)and progress-free survival(PFS)between the SLT and WGLT groups(P=0.910,P=0.190).CONCLUSION:Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.