摘要To evaluate the effectiveness and safety of Jinye Baidu Granules (金叶败毒颗粒) for acute upper respiratory tract infection(AURTI). Database such as CNKI, Wan-fang, VIP, SinoMed, Web of science, Clinical Trials gov, Medline、EMBASE, CENTRAL, Cochrane Library were retrieved to collect randomized controlled trials (RCTs) on Jinye Baidu Granules (金叶败毒颗粒) in treating AURTI from the estabslishment of the database to March 2019. A total of 2 reviewers independently screened the literature according to the inclusion and exclusion criteria, and extracted material and the quality evaluation of the included studies. Quality evaluation adopted Cochrane Handbook 5.1 evaluation standards and tools. RevMan5.3 was used to perform Meta-analysis for the adopted study. Finally a total of 4 RCTs involving 636 patients were included. Meta-analysis results showed that: compared with conventional Western medicine alone, Jinye Baidu Granules (金叶败毒颗粒) combined with Western medicine in the treatment of acute upper respiratory tract infection can improve the total effective rate of clinical efficacy [RR=0.13, 95％ CI (0.06, 0.29), P<0.00001], shorten the time of antipyretic time for acute upper respiratory tract infection [MD=–1.22,95％ CI (–1.43, –1.00), P<0.00001], shorten the time of pharyngeal pain [MD=–1.97, 95％ CI (–2.97, –0.96), P<0.0001] and shorten the cough disappear time [MD=–1.97, 95％ CI (–2.97, –0.96), P<0.0001]. There were 2 papers reporting adverse reactions during the study period, and one of them specifically reported diarrhea, nausea, vomiting and stomachache in the experimental group. In the control group: diarrhea, nausea and adverse reactions disappeared after drug withdrawal; the incidence of adverse reactions was 3.92％ in the control group and 5.88％ in the observation group. There was no significant difference between the 2 groups (P>0.05). Based on existing data and methods, the systematic evaluation showed that, compared with Western medicine alone, Jinye Baidu Granules (金叶败毒颗粒) combined with Western medicine alone could improve the total effective rate of clinical efficacy, reduce the time of fever, sore throat, and the disappearance of cough with less adverse reactions. However, due to the low quality of the included study, large samples, multicenter, randomized, double-blind trials and trials are still needed to randomized controlled trials with reference to the CONSORT standard and the STRICTA statement.