摘要Objective: To explore the clinical characteristics of Elemene Injection in the treatment of patients with esophageal cancer. Methods: A total of 310 patients diagnosed with esophageal cancer from the Hoptital Information System (HIS) of 21 hospitals across the country were selected in the study, and these patients all had been treated with Elemene Injection. In this study, the clinical general medication record information, diagnosis scheme information, general treatment information and combined medications information were analyzed by frequency statistics and association rules. Results: Elemene Injection was used most in patients aged 46-65 (177 cases, 57.10％); male patients were more than female. Among the main diagnoses of the most seasons and solar terms in hospitalization, the top three diagnoses were esophageal malignant tumor, malignant tumor, and hypertension. In terms of combination medication, the combination of western medicine blood substitutes and perfusion fluids, general nutritional drugs, vitamins, antibacterial drugs, and immune-promoting drugs were the main ones; the combination of traditional Chinese medicine was mainly anti-tumor drugs (48.71％). In addition, among the combination medications, the highest frequency of Elemene Injection combined with western medicine and traditional Chinese medicine were Xiaoaiping Injection (消癌平注射液) and ascorbic acid. Conclusion: The main susceptible people of esophageal cancer was middle-aged around 46-65, and there were more male patients than female; through the first diagnosis of western medicine, it can be found that in addition to patients suffering from esophageal cancer or other cancers, patients with high blood pressure, heart disease, and diabetes could use Elemene Injection. Therefore, when receiving such patients, attention should be paid to checking whether the patient had such diseases. At the same time, when using Elemene Injection, it's necessary to pay attention to certain combined medications to avoid adverse reactions.