摘要Objective: To compare the clinical effectiveness of gamma knife radiosugery combined with acupuncture therapy and microvascular decompression in the treatment of idiopathic trigeminal neuralgia. Methods: A total of 93 patients with primary trigeminal neuralgia added to Nanchang University Hospital from November 2016 to October 2018 were selected, it was divided randomly into the control group (45 cases) and the study group (48 cases). The control group was treated with microvascular decompression and the study group used gamma knife radiosurgery combined with acupuncture therapy. The study compared the immediate pain relief rate, Visual Analogue Scale (VAS) scores, completion rate, recurrence rate, hospitalization days, total treatment duration, total treatment cost and total effective rate of treatment in 2 groups. Results: Comparison of the same group after treatment: the VAS score with 24 hours of treatment in the control group was (5.33±0.49), with a significant difference from the pre-treatment VAS score (8.62±0.13); The VAS score with 24 hours of treatment in the study group was (5.96±0.58), with a significant difference from the pre-treatment VAS score (8.54±0.25). After treatment, immediate effect, parent effect, acute and chronic complements of the control group was 25, 5, 2 and 7 cases, and the study group was 6, 25, 7 and 1, respectively. There were significant differences between the two groups; The comparison of hospitalization days, total treatment duration, total treatment cost was statistically significant (P<0.05); There were no significant difference in immediate pain rate, VAS score, total incidence of complications, recurrence rate, and total effectiveness of treatment between the two groups (P>0.05). Conclusion: Both microvascular decompression and gamma knife radiosurgery combined with acupuncture therapy can safe and effective treatment idiopathic trigeminal neuralgia patients, and for patients with good health, can tolerance all-hemp surgery, there are contraindicaindications to acupuncture therapy, microvascular decompression treatment can be chosen, while patients who are weak, cannot tolerante all-hemp surgery or resist surgery, economic difficulties, and can choose gamma knife radiosurgery combined with acupuncture therapy treatment.