摘要The demand for Chinese-Western medicine collaboration has grown significantly,but current integration methods have substantial limitations.This article analyzes core issues in developing and implementing synergistic Chinese-Western medicine clinical treatment strategies and explores the transformation from traditional integration to genuine synergistic models.We analyzed methodological obstacles in synergistic strategy development through literature review and theoretical analysis,and explored applications of intelligent technology in strategy development.Four core challenges were identified:(1)Treatment timing coordination difficulties caused by different decision-making approaches,with Chinese medicine using syndrome-based assessments and Western medicine relying on standardized measurements;(2)Treatment selection complexities when integrating different types of evidence,lacking frameworks for evaluating and combining diverse evidence sources;(3)Obstacles in incorporating patient preferences systematically,with inadequate assessment methods and unclear integration mechanisms;(4)Implementation barriers in translating synergistic strategies into clinical practice,requiring changes in organizational structures,workflows,and evaluation systems.Large language models(LLMs)and other intelligent technologies offer technical support for addressing these methodological challenges.This article examines current challenges in developing synergistic Chinese-Western medicine clinical strategies,analyzing the shift from traditional integration toward synergistic approaches and identifying four core methodological obstacles.Exploring intelligent technology applications provides insights to inform future research directions and clinical practice development in integrated healthcare delivery.