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Comparative Evaluation of Antitumor Chinese Patent Medicine Injections Based on Evidence-Based Medicine and Markov Model

摘要Objective:The objective of this study was to explore the safety,efficacy,economy,and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection,rational drug use,public awareness of safe drug use,and medical insurance.Materials and Methods:The names of five frequently used antitumor Chinese patent medicine injections were used as search terms,including the compound Sophora flavescens injection,Kangai injection,Aidi injection,Kanglaite injection,and Brucea javanica oil emulsion injection.Relevant evidence-based medical research was extracted from the databases.A descriptive evaluation was conducted,and the Markov model was used for the cost-benefit analysis.Finally,the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method.Results:The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments,improving the quality of life for cancer patients,and reducing the incidence of adverse reactions.From the perspective of economy and other attributes,compound S.flavescens was superior to B.javanica oil,Aidi,Kangai,and Kanglaite.After a comprehensive evaluation of the above five injections,the compound S.flavescens injection received the highest score.Conclusions:Compound S.flavescens,Kangai,Aidi,B.javanica oil,and Kanglaite have their own advantages in effectiveness and no significant difference in safety.Compound S.flavescens injection has the highest comprehensive score.Clinical attention should be paid to monitoring the initial stage of medication and special groups.

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作者 Jing Yang [1] Yan-Peng Wang [2] Wen-Gong Yu [3] Yu-Yao Guan [2] Prince Emmanuel Opoku Amponsah [4] Xian-Shuai Tang [2] Ying-Zi Sun [2] Lei Zheng [2] 学术成果认领
作者单位 School of Medicine and Pharmacy,Ocean University of China,Qingdao,China;Department of Pharmacy,Shandong Medical College,Jinan,China;Department of Pharmacy,Cheeloo College of Medicine,Shandong Provincial Third Hospital,Shandong University,Jinan,China [1] Department of Pharmacy,Cheeloo College of Medicine,Shandong Provincial Third Hospital,Shandong University,Jinan,China [2] School of Medicine and Pharmacy,Ocean University of China,Qingdao,China [3] Biomedical Engineering Graduate School,University of Arizona,Tucson,AZ,USA [4]
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DOI 10.4103/2311-8571.395428
发布时间 2024-07-12
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