摘要Two-dimensional luminescent metal-organic frameworks(2D LMOFs),have garnered significant attention for their unique fluorescent properties and highly accessible active sites,yet designing these LMOFs with target-dependent fluorescence for sensing remains a challenging endeavor.Herein,a zinc tetra(4-carboxyphenyl)porphine(Zn-TCPP)LMOF was prepared and first applied to the fast and sensitive sensing of tetracycline hydrochloride(TCH).Upon TCH exposure,the signature red fluorescence of Zn-TCPP at 609 nm diminishes,accompanied by the emergence of a 520 nm peak,which were originated from photo-induced electron transfer(PET)of Zn-TCPP to TCH and inner filter effect(IFE)of TCH towards Zn-TCPP,and the triggers of Zn-TCPP on the instinct fluorescence of TCH,respectively.Notably,the I520 nm/I609 nm fluorescence intensity ratio showed good linearity over a wide range of TCH concentrations(0.1?25 μmol/L),with a limit of detection(LOD)of 65.4 nmol/L.Additionally,the Zn-TCPP probe showed good TCH selectivity and anti-interference properties.The probe's practicability was also validated by detecting TCH in spiked tap water,milk and chicken samples.Furthermore,test papers impregnated with the Zn-TCPP probe were prepared,allowing the visual detection of TCH with a smartphone.Results suggest the developed method is suitable for practical TCH detection.