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Limosilactobacillus reuteri CCFM1132 modulates gut microbiota and alleviates hyperuricemia:a randomized,double-blind,placebo-controlled trial

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摘要This randomized,double-blind,placebo-controlled trial evaluated the uric acid(UA)-lowering effect of Limosilactobacillus reuteri CCFM1132 in young males with hyperuricemia.Participants received 1 × 1010 CFU of L.reuteri CCFM1132(n=34)or placebo(n=31)daily for 8 weeks.After the intervention,serum UA concentration significantly decreased,along with a reduction in xanthine oxidase(XOD)activity compared to the placebo group(P＜0.01).Indicators of liver(aspartate transaminase and alanine transaminase)and renal(urea and creatinine)functions improved.Short-chain fatty acid(SCFA)concentrations significantly increased,with an upregulated abundance of SCFA producers(Fusicatenibacter,Ruminococcaceae UCG_014,and Ruminococcus 1)in the gut.Additionally,correlation analysis revealed that concentrations of SCFAs,particularly acetate and butyrate,were strongly negatively correlated with UA concentration and XOD activity.These findings suggest that L.reuteri CCFM1132 relieves hyperuricemia by enhancing the abundance of SCFA producers in the gut to promote SCFA production and by suppressing XOD activity.This study provides a valuable reference for developing new treatments for hyperuricemia.

作者 Lei Sun ^[1] Yang Cao ^[2] Feng Hang ^[3] Dongbo Yuan ^[4] Honglun Wang ^[5] Jianxin Zhao ^[3] Gang Wang ^[3] Guohong Qiao ^[4] Liyun Wang ^[6] 学术成果认领

作者单位 State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China ^[1] Department of Biostatistics,Harvard T.H.Chan School of Public Health,Boston MA 02115,USA ^[2] State Key Laboratory of Food Science and Resources,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;(Yangzhou)Institute of Food Biotechnology,Jiangnan University,Yangzhou 225004,China ^[3] Department of Clinical Laboratory,Yixing People's Hospital,Affiliated to Jiangsu University,Yixing 214200,China ^[4] Qinghai Provincial Key Laboratory of Tibetan Medicine Research,Xining 810008,China ^[5] Department of Endocrine Metabolism,Yixing People's Hospital,Affiliated to Jiangsu University,Yixing 214200,China ^[6]

关键词 Hyperuricemia Limosilactobacillus reuteri Xanthine oxidase Short-chain fatty acid Gut microbiota

DOI 10.26599/FSHW.2024.9250316

发布时间 2026-03-31（万方平台首次上网日期，不代表论文的发表时间）

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