摘要In recent years,the incidence of chronic inflammatory bowel disease(IBD)has been increasing,posing a serious threat to human health.Medication can lead to off-target,systemic side effects and serious complications,and safer treatments are urgently needed.Selenium(Se)supplementation can alleviate IBD by modulating gut flora and increasing antioxidant enzyme activities.Glutathione peroxidase(GPx)is a selenoprotein with good antioxidant capacity to eliminate inflammation and protect the intestinal.Herein,this paper comprehensively reviews the recent research progresses of Se-containing GPxs(GPx 1-4)in alleviating IBD with oxidation stress as the main thread,summaries the underlying mechanisms of Se-containing GPx on the regulation of IBD.The different effects of inorganic Se,organic Se,and Se nanoparticles in the treatment of IBD are discussed.