Clinical profile,etiology,and outcome of hemophagocytic lymphohistiocytosis associated with histiocytic necrotizing lymphadenitis

二维码有效期 120s

摘要Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening clinical syndrome characterized by aberrantly activated macrophages and cytotoxic T cells,leading to mul-tiple organ failure[1].The main manifestations included recurrent fever,cytopenia,liver dysfunction,and sepsis-like syndrome.Physicians should be fully aware of HLH since early diagnosis and management may prevent irreversible organ failure and subsequent death.Treatment protocols,such as HLH-94 based on etoposide(VP 16),are commonly used in clinical practice,especially in familial HLH[2]and malignancy-associated HLH[3].

作者 Kuang-Guo Zhou ^[1] Duan-Hao Gong ^[1] Dan Peng ^[2] Zhi-Qiong Wang ^[1] Wei Huang ^[1] 学术成果认领

作者单位 Department of Hematology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Jiefang Road 1095#,Wuhan 430030,China ^[1] Department of Nuclear Medicine,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,China ^[2]

栏目名称 Research letters

发布时间 2023-05-30

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