摘要Background During the coronavirus disease 2019(COVID-19)pandemic,there is an urgent need for safe and effective COVID-19 vaccines to protect children and adolescents.This study aims to provide scientific evidence and recommendations for the application of COVID-19 vaccines in children and adolescents by analyzing the latest studies.Methods We systematically searched MEDLINE(accessed through PubMed),Embase,and Web of Science from January 1,2020,to October 8,2022.Eligible clinical trials,cohort studies,case-control studies,and cross-sectional studies with extractable data were included in immunogenicity,effectiveness,and safety analyses.According to the heterogeneity,we chose a fixed-effect model(when I2 ≤ 50)or a random-effects model(when I2＞50)to pool effect values.Results A total of 88 articles were included.The seroconversion rates after the first,second,and third doses of the vac-cines were 86.10％,96.52％,and 99.87％,respectively.After the first and second doses,vaccine effectiveness(VE)against severe acute respiratory syndrome coronavirus 2 infection was 42.87％[95％confidence interval(CI)=27.09％-58.65％]and 63.33％(95％CI=52.09％-74.56％),respectively.After the first and second doses,VE against COVID-19 was 60.65％(95％CI=44.80％-76.50％)and 75.77％(95％CI=63.99％-87.56％),respectively.VE against hospitalization due to COVID-19 after the first and second doses was 72.74％(95％CI=51.48％-94.01％)and 82.78％(95％CI=75.78％-89.78％),respectively.The most common adverse events were injection site pain,fatigue/asthenia/tiredness,headache,myalgia/muscle pain,and chills.The incidence rate of myocarditis or pericarditis was 2.42/100,000 people.In addition,the subgroup analysis showed that children aged ≤ 5 years had the lowest incidence of adverse events,and the incidence rate of adverse events was higher for mRNA vaccines than for inactivated vaccines.Conclusions COVID-19 vaccines have good immunogenicity,effectiveness,and safety among children and adolescents.We recommend that children and adolescents be vaccinated as soon as possible to protect them and slow the spread of COVID-19.