摘要Background Myocarditis is one of the presentations of multisystemic inflammatory syndrome in children(MIS-C)following coronavirus disease 2019(COVID-19).Although the reported short-term prognosis is good,data regarding medium-term functional capacity and limitations are scarce.This study aimed to evaluate exercise capacity as well as possible cardiac and respiratory limitations in children recovered from MIS-C related myocarditis.Methods Fourteen patients who recovered from MIS-C related myocarditis underwent spirometry and cardiopulmonary exercise testing(CPET),and their results were compared with an age-,sex-,weight-and activity level-matched healthy control group(n=14).Results All participants completed the CPET with peak oxygen uptake(peak V O2),and the results were within the normal range(MIS-C 89.3％±8.9％and Control 87.9％±13.7％predicted V O2).Five post-MIS-C patients(35％)had exercise-related cardio-respiratory abnormalities,including oxygen desaturation and oxygen-pulse flattening,compared to none in the control group.The MIS-C group also had lower peak exercise saturation(95.6±3.5 vs.97.6±1.1)and lower breathing reserve(17.4％±7.5％vs.27.4％±14.0％of MVV).Conclusions Patients who recovered from MIS-C related myocarditis may present exercise limitations.Functional assess-ment(e.g.,CPET)should be included in routine examinations before allowing a return to physical activity in post-MIS-C myocarditis.Larger,longer term studies assessing functional capacity and focusing on physiological mechanisms are needed.