摘要Purpose Cancer predisposition syndromes are genetic disorders that significantly raise the risk of developing malignancies.Although the malignant manifestations of cancer predisposition syndromes are well-studied,recognizing their non-malignant features is crucial for early diagnosis,especially in children and adolescents.Methods A comprehensive literature search was conducted using the PubMed database,focusing on non-malignant manifes-tations of cancer predisposition syndromes in children and adolescents.Key sources included the Clinical Cancer Research pediatric oncology series and ORPHANET.Studies that described clinical signs and symptoms affecting specific organ systems were included.Results Non-malignant dermatological features often serve as early indicators of cancer predisposition syndromes,includ-ing café-au-lait spots in Neurofibromatosis Type 1 and facial angiofibromas in Tuberous Sclerosis Complex.Neurological and developmental anomalies such as cerebellar ataxia in ataxia-telangiectasia and intellectual disabilities in neurofibroma-tosis type 1 and tuberous sclerosis complex are significant indicators.Growth and metabolic anomalies are also notable,including overgrowth in Beckwith-Wiedemann syndrome and growth hormone deficiency in neurofibromatosis Type 1.In addition,facial anomalies,ocular manifestations,hearing issues,and thyroid anomalies are prevalent across various cancer predisposition syndromes.For instance,hearing loss may be significant in neurofibromatosis Type 2,while thyroid nodules are common in PTEN hamartoma tumor syndrome and DICER1 syndrome.Cardiovascular,abdominal,musculoskeletal,pulmonary,genitourinary manifestations,and prenatal deviations further complicate the clinical picture.Conclusions Recognizing non-malignant features of cancer predisposition syndromes is essential for early diagnosis and management.This organ-specific overview furthers awareness among healthcare providers,facilitating timely genetic coun-seling,surveillance programs,and preventive measures,ultimately improving patient outcomes.