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Gaps and challenges in the management of pediatric steatotic liver diseases:a narrative review

摘要Background Given the rising prevalence of pediatric steatotic liver disease(SLD),it is imperative to identify and address common challenges in clinical practice.This article aims to examine key issues in managing pediatric SLD and attempts to propose evidence-based recommendations.Data sources We reviewed published literature on steatotic liver diseases in children focusing on overweight and obesity,including original research,systematic reviews,meta-analyses,consensus statements,and position papers.Databases searched were PubMed/MEDLINE,Cochrane Library,Web of Science,and Scopus.Search terms included:"non-alcoholic fatty liver disease","NAFLD","steatohepatitis","NASH","steatotic liver disease","fatty liver","children","adolescents","pediatric","obesity",and"overweight".Results Critical issues include an over-reliance on liver biochemistry,which may fail to capture the broader spectrum of SLD[e.g.,metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction associated with steatohepatitis(MASH)],and delays in recognizing metabolic comorbidities.Dietary and lifestyle recommendations are often generalized,overlooking individual patient needs,while psychological factors,such as stress and mental health,are frequently neglected despite their role in disease progression.Advanced fibrosis cases are under-referred,long-term risks like cirrhosis are underestimated,and insufficient follow-up,coupled with limited family involvement in education,further compromises care.Conclusions Addressing these deficiencies through a multidisciplinary approach that incorporates early diagnosis,per-sonalized treatment strategies,structured monitoring,and comprehensive family involvement is imperative for optimizing outcomes and mitigating the long-term impact of pediatric SLD.

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作者 Wathsala Hathagoda [1] Shaman Rajindrajith [1] Madunil Anuk Niriella [2] 学术成果认领
作者单位 Department of Paediatrics,Faculty of Medicine,University of Colombo,Kynsey Road Colombo 8,Colombo 00800,Sri Lanka;University Paediatric Unit,Lady Ridgeway Hospital for Children,Danister de Silva Road,Colombo 08,Colombo 00800,Sri Lanka [1] Colombo North Centre for Liver Diseases,Faculty of Medicine,University of Kelaniya,Thalagolla Road,Ragama,11010,Sri Lanka [2]
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DOI 10.1007/s12519-025-00902-w
发布时间 2025-06-16(万方平台首次上网日期,不代表论文的发表时间)
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