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Management of pulmonary thromboembolism in children:an evidence-based expert consensus

摘要Background Pulmonary thromboembolism is rare in children,but can be life-threatening.Timely diagnosis and treat-ment of pulmonary thromboembolism are crucial for reducing mortality associated with pulmonary thromboembolism in children.While guidelines for pulmonary thromboembolism in adults are available,guidelines for standardized diagnosis and management of pulmonary thromboembolism in children are not.This expert consensus aims to provide recommendations for the management of pulmonary thromboembolism in children based on the current best available evidence.Data sources Following the World Health Organization Handbook for Guideline Development,the expert panel consisted of 30 members from different clinical areas.The panel identified clinical questions through systematic reviews and expert discussions,systematically reviewed evidence on pulmonary thromboembolism in children,and evaluated the quality of the evidence using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)approach.Using the GRADE Evidence to Decision Framework,the panel made recommendations,considering the effects of interventions,resource use,values and preferences,equity,acceptability,and feasibility.Results The epidemiology,classification,and pathophysiology characteristics are summarized.The expert panel developed 33 recommendations addressing 20 questions related to diagnosis steps,treatment approaches such as anticoagulant therapy,thrombolysis therapy,catheter-based interventional therapy,surgical embolectomy,multidisciplinary team,and treatment of patients with comorbidities,prognosis,education,as well as follow-up.Among these,18 are weak recommendations based on very low quality evidence,and 15 are good practice statements.Conclusions The expert panel provided recommendations for pulmonary thromboembolism in children based on available evidence,which was generally low in quality and volume.The panel urges further research on early iden-tification and diagnosis strategies,preventive and therapeutic regimens,and long-term management for pulmonary thromboembolism.

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作者 Li-Nan Zeng [1] Ying-Xue Zou [2] Hai-Lin Zhang [3] Li-Na Chen [4] De-Hui Chen [5] Xin-Xin Chen [6] Xing Chen [7] Zhi-Min Chen [8] Xiao-Yan Dong [9] Liang Huang [10] Yi Ji [11] Yong-Mei Jiang [12] Zhi-Ping Li [13] En-Mei Liu [14] Shu-Hua Luo [4] Xiao-Feng Ni [1] Guang-Min Nong [15] Yun Peng [16] Su-Yun Qian [17] Tian-You Wang [18] Xin-Yu Yuan [19] Hao Zhang [20] Hong Zhang [21] Xiao-Bo Zhang [22] De-Yu Zhao [23] Shun-Ying Zhao [24] Xiu-Fang Zhao [25] Kai-Yu Zhou [26] Quan Lu [9] Ling-Li Zhang [27] Han-Min Liu [28] 学术成果认领
作者单位 Department of Pharmacy/Evidence-Based Pharmacy Center,West China Second University Hospital,Sichuan University;Children's Medicine Key Laboratory of Sichuan Province,Chengdu,China;NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation,Chengdu,China;Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China;West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,China [1] Department of Pulmonology,Tianjin Children's Hospital(Children's Hospital of Tianjin University),Tianjin,China [2] Department of Pediatric Respiratory Medicine,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China [3] Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu,China [4] Department of Pediatrics,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,China [5] Heart Center,Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,China [6] Department of Pediatrics,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,China [7] Department of Pulmonology,Children's Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,China [8] Department of Pulmonology,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [9] Department of Pharmacy/Evidence-Based Pharmacy Center,West China Second University Hospital,Sichuan University;Children's Medicine Key Laboratory of Sichuan Province,Chengdu,China;NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation,Chengdu,China;Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China [10] Department of Pediatric Surgery,West China Hospital,Sichuan University,Chengdu,China [11] Department of Laboratory Medicine,West China Second University Hospital,Sichuan University,Chengdu,China [12] Department of Clinical Pharmacy,National Children's Medical Center,Children's Hospital of Fudan University,Shanghai,China [13] Department of Respiratory Medicine,Children's Hospital of Chongqing Medical University,Chongqing,China [14] Department of Pediatrics,The First Affiliated Hospital of Guangxi Medical University,Nanning,China [15] Department of Radiology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,China [16] Pediatric Intensive Care Unit,Beijing Children's Hospital,Capital Medical University,Beijing,China [17] Hematology Center,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,China [18] Department of Radiology,The Affiliated Children's Hospital,Capital Institute of Pediatrics,Beijing,China [19] Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease,Shanghai Children's Medical Center,National Children's Medical Center,Shanghai Jiaotong University School of Medicine,Shanghai,China [20] Department of Clinical Laboratory,Shanghai Children's Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [21] Department of Respiratory Medicine,Children's Hospital of Fudan University,Shanghai,China [22] Department of Respiratory Medicine,Children's Hospital of Nanjing Medical University,Nanjing,China [23] Department of Respiratory Disease,Beijing Children's Hospital,Capital Medical University,Beijing,China [24] Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China;Department of Nursing,West China Second University Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu,China [25] Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China;Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu,China [26] Department of Pharmacy/Evidence-Based Pharmacy Center,West China Second University Hospital,Sichuan University;Children's Medicine Key Laboratory of Sichuan Province,Chengdu,China;NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation,Chengdu,China;Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China;West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu,China;Chinese Evidence-Based Medicine Center,West China Hospital,Sichuan University,Chengdu,China [27] Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,China;Department of Pediatric Pulmonology and Immunology,West China Second University Hospital,Sichuan University,Chengdu,China;NHC Key Laboratory of Chronobiology(Sichuan University),Chengdu,China;The Joint Laboratory for Lung Development and Related Diseases of West China Second University Hospital,Sichuan University and School of Life Sciences of Fudan University,West China Institute of Women and Children's Health,West China Second University Hospital,Sichuan University,Chengdu,China;Sichuan Birth Defects Clinical Research Center,West China Second University Hospital,Sichuan University,Chengdu,China [28]
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DOI 10.1007/s12519-025-00987-3
发布时间 2026-05-06(万方平台首次上网日期,不代表论文的发表时间)
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世界儿科杂志(英文版)

世界儿科杂志(英文版)

2026年22卷3期

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