换一批摘要Nuclear DNA helicase Ⅱ(NDH Ⅱ),or RNA helicase A(RHA),was initially discovered in mammals by conventional protein purification methods.Molecular cloning identified apparent sequence homologies between NDH Ⅱ and a Drosophila protein named maleless(MLE),the latter being essential for the Drosophila X-chromosome dosage compensation.Increasing amounts of evidence suggest that NDH Ⅱ is involved in multiple aspects of cellular and viral DNA and RNA metabolism.Moreover the functions of NDH Ⅱ may have potential clinical implications related to viral infection,autoimmune diseases,or even tumorigenesis.
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关键词
DNA and RNA helicasemaleless (MLE)X-chromosome dosage compensationdsRBDRGG-boxtranscriptionRNA processingRNA transportactinnucleolusSLE (systemic lupus erythematosus)virus
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Q5（生物化学）
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发布时间
2007-07-26（万方平台首次上网日期，不代表论文的发表时间）
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