Engineered hydrogels for brain tumor culture and therapy

二维码有效期 120s

摘要Brain tumors' severity ranges from benign to highly aggressive and invasive. Bioengineering tools can assist in understanding the pathophysiology of these tumors from outside the body and facilitate development of suitable antitumoral treatments. Here, we first describe the physiology and cellular composition of brain tumors. Then, we discuss the development of three-dimensional tissue models utilizing brain tumor cells. In particular, we highlight the role of hydrogels in providing a biomi-metic support for the cells to grow into defined structures. Microscale technologies, such as electrospinning and bioprinting, and advanced cellular models aim to mimic the extracellular matrix and natural cellular localization in engineered tumor tissues. Lastly, we review current applications and prospects of hydrogels for therapeutic purposes, such as drug delivery and co-administration with other therapies. Through further development, hydrogels can serve as a reliable option for in vitro modeling and treatment of brain tumors for translational medicine.

作者单位 Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA;Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA ^[1] Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA ^[2] Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA;Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA ^[3] Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA;Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California-Los Angeles, Los Angeles, CA 90095, USA ^[4] Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA;Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA;Department of Radiological Sciences, University of California-Los Angeles, Los Angeles, CA 90095, USA;Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA;Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90024, USA ^[5]

关键词 Brain tumor Bioengineering Cancer cells Drug delivery Hydrogel

栏目名称 REVIEWS

发布时间 2020-07-23

基金项目

The authors also acknowledge funding from the National Institutes of Health