摘要Chronic diabetic wounds result from a disrupted microenvironment where oxidative stress,impaired angiogenesis,and per-sistent infection create a vicious cycle that delays healing.Unfortunately,existing treatments often fail to address these inter-related issues,resulting in suboptimal healing.Here,we propose a base-tip dual-component hydrogel microneedle(MN)system(GBEVs-pVEGF/AgNPs@MNs),consisting of a tip loaded with plant-bacterial hybrid extracellular vesicles(GBEVs-pVEGF)and a base containing silver nanoparticles(AgNPs).Upon penetrating the necrotic tissue of diabetic wounds,our multifunc-tional MNs could effectively deliver GBEVs-pVEGF,thereby alleviating oxidative stress,promoting cell migration,and facili-tating angiogenesis.Additionally,the physical barrier formed by the basal layer synergistically mitigates persistent bacterial infections during wound healing in conjunction with the antimicrobial agent AgNPs.This multifunctional MN system,inte-grating antioxidant,angiogenic,and antimicrobial properties,effectively restores the disrupted wound microenvironment,offer-ing significant potential for accelerating diabetic wound healing.