摘要The SafeAmpCase is an innovative 3D-printed solution developed to address critical challenges in transporting and storing fragile glass drug ampoules during emergencies.This study employs a multidisciplinary approach—integrating biomedical engineering,advanced materials science,and emergency medicine expertise—to develop a compact,durable,and user-friendly ampoule case.A key innovation lies in the strategic selection of thermoplastic polyurethane(TPU)as the material,leveraging its superior impact resistance,flexibility,and noise-damping characteristics to ensure reliability under performance in demanding real-world conditions.To optimize the 3D printing process,key parameters,including printing temperature(220-250 ℃),volu-metric flow rate(3-20 mm3/s),retraction speed(30-90 mm/s),and retraction length(0.4-1.2 mm),were systematically adjusted using calibration models.The final optimized parameters(245 ℃,7 mm3/s,90 mm/s,and 1.2 mm)reduced produc-tion time by 43％while preserving structural integrity.American Society for Testing and Materials(ASTM)international stan-dard drop tests confirmed the case's exceptional impact resistance,demonstrating a 90％reduction in ampoule breakage com-pared to polylactic acid plus.Further refinements,guided by feedback from 25 emergency professionals,resulted in medication-specific color coding and an enhanced locking mechanism for usability in high-pressure situations.The final SafeAmpCase model withstood 18 consecutive drop trials without ampoule breakage,confirming its robustness in field conditions.This research underscores the transformative potential of additive manufacturing in developing customized,high-performance solutions for critical healthcare applications,setting a new benchmark for biomedical device design and rapid prototyping.