摘要The specific surface area(SS)and pore size(D)exhibit an inherent trade-off in the microscale design of bone implants:larger pores typically correlate with reduced surface area and vice versa.This relationship has attracted notable attention be-cause of its critical role in the regulation of cell adhesion and osteogenesis.However,it remains largely unclear how SS and D affect the generated bone tissue and dynamically change during long-term osteogenesis.Herein,by applying rigorous geo-metric mapping to minimal surfaces,we constructed precisely partitioned and layer-by-layer thickened tissue models to simu-late osteogenesis across different temporal scales and thereby track the dynamic evolution of geometric characteristics,per-meability,and mechanobiological tissue differentiation.The high-SS samples were found to facilitate the rapid formation of new bone tissue in the early stages.However,their smaller pores tended to cause occlusions,hindering further tissue devel-opment.In contrast,low-SS samples showed slower bone regeneration,but their larger pores provided adequate physical space for tissue regeneration and mass transport,ultimately promoting bone formation in the long term.Mechanobiological regulation suggests that fibrous tissue formation inhibits additional bone formation,establishing a dynamic equilibrium be-tween osteogenesis and pore space to sustain nutrient/waste exchange throughout the regenerative process.Overall,smaller pores are preferable in implants for minimally loaded osteoplasty procedures focused on early-stage bone consolidation,whereas larger pores are preferable in dynamically loaded implants requiring prolonged mechanical stability.