摘要Biofabrication and biomanufacturing are rapidly transforming how materials,therapeutics,and functional biological constructs are produced.These fields integrate developments in sustainable biomaterials,precision fabrication,biological systems,and data-driven engineering to produce scalable,efficient,and environmentally aligned production pathways.This review high-lights recent scientific advances led by researchers in Singapore,focusing on three interconnected pillars:sustainable bio-derived materials,enabling fabrication and manufacturing technologies,and emerging applications.We first examine the ex-panding use of biomass-derived feedstocks,including human hair keratin,aquaculture side-streams,and plant-derived polysac-charides,which support circular and resource-conscious material development.We then present advances in biofabrication technologies,including electrospinning,three-dimensional bioprinting,and metal additive manufacturing,that enable im-proved control over the structure,function,and manufacturability of biomedical and functional constructs.Emerging applica-tions,such as machine learning-assisted additive manufacturing,food biomanufacturing,regenerative cell therapy,mi-croneedles,and bioelectronics,exemplify how biofabrication and biomanufacturing are increasingly interrelated across the health,materials,and technological domains.These research contributions from Singapore exemplify how sustainable feed-stocks,digital and automated fabrication platforms,and biologically driven applications are shaping the evolving landscape of biofabrication and biomanufacturing.The convergence of materials science,biological engineering,and advanced manu-facturing continues to enable new opportunities for innovation in biomedical,industrial,and societal contexts.