摘要目的:探讨室间隔缺损（VSD）合并心力衰竭（心衰）患儿红细胞钙离子的代谢变化。方法:正常对照组12人，VSD无心衰组10人，VSD合并心衰组21人。测定其红细胞内Ca 2+浓度（［Ca 2+］）、 45Ca跨膜流动及膜ATPase活性。 结果:VSD合并心衰时红细胞内［Ca 2+］及 45Ca净摄取较对照组显著增加， 45Ca单向性内流无变化，而膜Ca 2+-Mg 2+ATP ase和Na +-K + ATPase活性则明显下降。 结论:心衰时细胞内［Ca 2+］增高不是细胞膜对Ca 2+的通透性改变所致，而与细胞排Ca 2+能力下降有关；VSD并心衰患儿细胞内Ca 2+代谢变化是由于VSD导致血液动力学改变后，引起机体代谢变化，而随之发生变化的。

abstractsObjective:To search for the changes of intraerythrocytic Ca 2+ metabolism in the children with ventricular septal defect (VSD) complicated by heart failure (HF) . Method:There were 43 children,and divided into 3 groups. 12 normal children were entered into group 1 as control. The group 2 was 10 VSD patients without HF. The group 3 was 21 VSD patients complicated with HF. The intraerythrocytic Ca 2+ concentration ( [Ca 2+] ) ,Ca 2+ influx and the activities of ATP ase in erythrocytic membrance were measured. Results:The intraerythrocytic[Ca 2+] and the amount of 45Ca net uptake were significantly higer, 45Ca oneway influx of erythrocyte remained unchange,the activities of Ca 2+-Mg 2+ ATP ase and Na +-K + ATPase in erythrocytic membrance in HF group were obviously lower than that in control group. Conclusion:The penetrance of cell membrance in HF group was normal,The ATP ase activities in membrance were decreased,while the capability of Ca 2+ removal of cell decreased,the concentration of intracellular Ca 2+ raised.