摘要全身型幼年特发性关节炎(sJIA)是一种以关节炎伴发热、皮疹和浆膜炎等全身表现为主要特征的自身炎症性疾病.由于其症状不典型、预后不佳,在临床诊断和疗效评估方面存在极大挑战.生物标志物可以用来评价疾病的严重程度、预测疾病活动和转归.现主要从遗传学标志、血清学标志和细胞学标志3个方面对已有sJIA的生物标志物研究结果及在临床诊疗中的应用进行阐述.

abstractsSystemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized with arthritis in one or more joints,fever,rash and serositis.Due to the atypical symptoms and poor prognosis,it's a great challenge in the clinical diagnosis and treatment efficacy evaluation in sJIA.These challenges could be addressed by the identification of clinical biomarkers,aiming at evaluating the disease severity,predicting the activity and prognosis of sJIA.This review will be focus on genetics,serum and cellular markers in sJIA and summarize the relative application on diagnosis and treatment.