摘要随着社会生活水平的提高及全球的重视，儿童结核病的诊治水平得到很大提高，但儿童结核病仍然是重大的社会卫生问题，目前公认接种卡介苗(BCG)是预防重症结核感染的重要手段之一。我国是结核高负荷国家，BCG是国家免疫规划儿童常规出生接种的疫苗。绝大多数婴儿接种BCG后无不良反应，少部分婴儿会发生BCG感染，严重者发生播散性感染甚至死亡。现就BCG常见异常反应进行阐述，并呼吁关注严重异常反应背后的原发性免疫缺陷病。

abstractsPediatrics tuberculosis remains a global public health problem, despite substantial progress in the diagnosis and treatment of this disease due to the improvement of social living standards and increasing global attention.Bacillus Calmette-Guerin (BCG) is recognized as one of the important means to prevent severe tuberculosis infection.As a country with high burden of tuberculosis, China classifies BCG as a vaccine for routine immunization of children in the national immunization programs.Most infants have no adverse reactions after BCG vaccination with, but a small number of babies will develop BCG infection, disseminated infection and even death in severe cases.In this article, the common adverse reactions were described, and it appealed that attention should be paid to the primary immunodeficiency diseases behind severe abnormal reactions.